How to sequence your own DNA at home
93 points by bilsbie 4 hours ago | 23 comments
__MatrixMan__ 49 minutes ago
I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would.
reply$100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people
Aurornis 4 hours ago
I wish this had some discussion of the results. The earlier reports about this sensor and process were very mixed. It’s a cool process either way, but I’d like to know how usable the real world output can be.
replydwa3592 3 hours ago
This is so cool. Thanks for doing this. The fact that we have this in a palm sized object is just crazy. Also, if/when we have a similar sized device for doing CRISPR .... umm i should stop here - it's becoming the plot of Gattaca
replymephux 3 hours ago
https://www.the-odin.com/whole-genome-sequencing-30x/
replyIf you want it quick and cheap(er) - 599.00
drdaeman 3 hours ago
If it's an US-based lab, aren't they subject to CLIA with all its retention requirements?
replyFor $7.5k+ you get a guaranteed privacy (as other comments suggest, other properties may vary, but at least the data never leaves your home).
armanj 47 minutes ago
one main marketing leverage of 23andMe, AncestryDNA, etc are fulfilling the curiosity of people who want to know which part of the world their genes are from. I guess that dataset should be preparatory.
replywhatever1 4 hours ago
What is the accuracy in this ? Aka if I run the experiment 10 times how many differences will i get? I don’t have a physical sense on what would be a good number.
replymyhf 3 hours ago
You would get a lot of differences, but the errors would cancel each other out with enough depth of coverage.
replyThis technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.
Jules-Bertholet 3 hours ago
> so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other
replyThis assumes random errors, which IIRC isn't the case for Oxford Nanopore.
Jules-Bertholet 3 hours ago
Oxford Nanopore unfortunately has a high error rate (3-5%) compared to other sequencing technologies. And the errors are non-random
replymetalman 3 hours ago
I am very impressed with the, why wait? just do it now approach to the future.
which while not here, IS there.
replydekhn 3 hours ago
Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.
replyElenaDaibunny 18 minutes ago
just a hobby project for now,pretty wild that this can be done at home.
replybleepblap 3 hours ago
> This is intended to be read by AI
replyFuck this
tclancy 2 hours ago
Man, doctors thought they had it bad before. For just a six yards I can play Peter Thiel at home! $6k invested so I can set an AI in YOLO mode to tell me I have some hyper-specific version of kennel cough?
reply“But that occurs in dogs?”
“You’re right. Let me look into actual gene sequencing instead of just guessing. I think the N is the load bearing letter.”
What kind of magic is going on here, am I missing something?